Citrus Flavonoids are Potent Metabolic Boosters & Anti-carcinogens

Special types of citrus-derived flavonoids Plant compound that is associated with pigmentation. Flavonoids have been shown to modify allergens, viruses, inflammation, and various carcinogens. Found in green tea, citrus, berries, onions, parsley, red wine, dark chocolate, and others., known as polymethoxyflavones, especially nobiletin Type of citrus bioflavonoid shown to have anti-inflammatory, anti-oxidant, and blood sugar support properties. and tangeretin Special type of citrus bioflavonoid shown to reduce the risk for certin cancers, protecting nerve cells, and involved with healthy cholesterol function., are inversely associated with cardiovascular disease.  Previous studies have shown them to be effective in lowering cholesterol¹ in humans as well as helping to prevent the accumulation of LDL cholesterol Low-density lipoprotein. It is a group of lipids and proteins that allow lipids like cholesterol, triglycerides, and fat soluble nutrients (Vitamin A, D, E , K, Q 10, carotenes) to be transported with the water-based bloodstream. ² in the lining of arteries.  Even relatively small amounts of them can activate gene signals that help to correctly metabolize cholesterol³.  A new study shows that nobiletin Type of citrus bioflavonoid shown to have anti-inflammatory, anti-oxidant, and blood sugar support properties. can boost adiponectin Protein hormone that modulates metabolism including glucose and fatty acid catabolism. High levels are associated with low body fat. levels and reduce inflammation within white adipose tissue, thereby significantly improving insulin resistance and lowering high blood sugar.  Additionally, a significant body of research has been accumulating in the past few years showing that polymethoxflavones are powerful nutrients in cancer prevention.

There are at least 4000 flavonoids Plant compound that is associated with pigmentation. Flavonoids have been shown to modify allergens, viruses, inflammation, and various carcinogens. Found in green tea, citrus, berries, onions, parsley, red wine, dark chocolate, and others. identified in nature.  These health-protecting substances are widely found in fruits, vegetables, and spices.  Sometimes flavonoids Plant compound that is associated with pigmentation. Flavonoids have been shown to modify allergens, viruses, inflammation, and various carcinogens. Found in green tea, citrus, berries, onions, parsley, red wine, dark chocolate, and others. are naturally attached to other molecules that enhance their ability to be absorbed and utilized within your body.  These are often top choices for dietary supplements.  One such class of flavonoid, now generating extensive scientific research, is the polymethoxyflavones. 

A polymethoxyflavone is a nutrient structure with more than one methyl group (-CH3) already attached to the flavonoid.  The most active forms are found in the seldom-eaten peels and contain 5 – 7 methyl groups attached to one flavonoid.  This unique “package” enables the nutrient to be better absorbed as well as maintaining its biological activity for a longer period of time.  It also helps transport flavonoids Plant compound that is associated with pigmentation. Flavonoids have been shown to modify allergens, viruses, inflammation, and various carcinogens. Found in green tea, citrus, berries, onions, parsley, red wine, dark chocolate, and others. to places that methyl groups like to go – which turns out to be incredibly important for protecting the DNA of your cells and thereby reducing your risk for cancer.

This topic is best understood by realizing the overall importance of the process of methylation within your body, which is a key to your health in the first place.  Vitamin B12 and folic acid work in harmony to orchestrate this process – which is yet another reason why the coenzyme Enzyme in its most active form that assists with biochemical transport and is considered an active constituent. forms of B vitamins are so vital to your health.  For example, when you take pre-methylated B12 (methylcobalamin), instead of cheap cyanide-producing B12 (cyanacobalamin), then you are using the form of the B vitamin that directly facilitates methylation processes within your body (not to mention far superior absorption of the nutrient). 

A recent study demonstrated that nobiletin Type of citrus bioflavonoid shown to have anti-inflammatory, anti-oxidant, and blood sugar support properties. was highly protective to the brain⁵, inhibiting the brain tangles that cause Alzheimer’s.  Nobiletin had a specific impact on offsetting fear conditioning, indicating a unique benefit for those with anxiety.  Of course, nerve-related methylation is vital to normal nerve function which is also why B12 and folic acid are so vital to basic nerve health.

Scientists now recognize that an overall deficiency in methylation activity causes general DNA instability and increases the risk for DNA mutation, i.e., cancer.  Scientists have focused a considerable amount of research on the importance of methyl-containing compounds and their metabolism within your body. Three years ago a comprehensive review of nobiletin Type of citrus bioflavonoid shown to have anti-inflammatory, anti-oxidant, and blood sugar support properties. and tangeretin Special type of citrus bioflavonoid shown to reduce the risk for certin cancers, protecting nerve cells, and involved with healthy cholesterol function. in their anti-cancer role was published by a researcher from the Medical University of South Carolina (read entire article by clicking here⁶).

He reviews the science that demonstrates how nobiletin Type of citrus bioflavonoid shown to have anti-inflammatory, anti-oxidant, and blood sugar support properties. and tangeretin Special type of citrus bioflavonoid shown to reduce the risk for certin cancers, protecting nerve cells, and involved with healthy cholesterol function. are able to stabilize DNA against exposure to carcinogenic environmental toxins (which all humans are continuously exposed to).  Furthermore, the science supporting the use of nobiletin Type of citrus bioflavonoid shown to have anti-inflammatory, anti-oxidant, and blood sugar support properties. and tangeretin Special type of citrus bioflavonoid shown to reduce the risk for certin cancers, protecting nerve cells, and involved with healthy cholesterol function. to reduce the progression of cancer is reviewed.  These nutrients act at the gene level to lower excessive NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. and related gene signaling that is otherwise essential in the spreading of cancer.

In support of earlier research a recent study showed that nobiletin Type of citrus bioflavonoid shown to have anti-inflammatory, anti-oxidant, and blood sugar support properties. and tangeretin Special type of citrus bioflavonoid shown to reduce the risk for certin cancers, protecting nerve cells, and involved with healthy cholesterol function. could protect the liver⁷ against exposure to cancer-causing carbon tetrachloride (solvent/cleaning chemical), acetaminophen (Tylenol), and highly inflammatory lipopolysaccharide (bacterial cell-wall toxins).  These nutrients lowered various inflammatory markers, TNFa Cytokine involved with systemic inflammation and regulation of immune cells. It is able to induce cell death, and inhibits tumorigenesis and viral replication. When dysfunctional it is associated with a number of disease processes. and iNOS Inducible Nitric Oxide Synthase. This enzyme influences genes located in the neuro-immune and cardiovascular system and provides immune defense against pathogens and contributes to disease progression including neurogenic inflammation (iNOS2). , which means there will be much less free radical damage (including potential DNA damage).

In a just published study an extract of polymethoxyflavones containing nobiletin Type of citrus bioflavonoid shown to have anti-inflammatory, anti-oxidant, and blood sugar support properties. and tangeretin Special type of citrus bioflavonoid shown to reduce the risk for certin cancers, protecting nerve cells, and involved with healthy cholesterol function. killed five different human cancer cell types⁸.  The researchers concluded that polymethoxyflavones “may help prevent cervical cancer and may potentially be a useful agent for the treatment of certain malignancies.”

In cases of chemotherapy drug resistance it is typical that cancer cells pump the toxic drug back out of the cell as fast as it goes in.  This is based on the activity of a transporter system known as p glycoprotein.  In a model of chemo drug resistance nobiletin Type of citrus bioflavonoid shown to have anti-inflammatory, anti-oxidant, and blood sugar support properties. and tangeretin Special type of citrus bioflavonoid shown to reduce the risk for certin cancers, protecting nerve cells, and involved with healthy cholesterol function. were found to blunt the activity of p glycoprotein in this context so that cancer cells were forced to build up a higher level of the chemo drug.  Another new study showed that tangeretin Special type of citrus bioflavonoid shown to reduce the risk for certin cancers, protecting nerve cells, and involved with healthy cholesterol function. can directly kill leukemia cells¹⁰, an effect that was enhanced in combination with a chemo drug.  And yet another study showed that tangeretin Special type of citrus bioflavonoid shown to reduce the risk for certin cancers, protecting nerve cells, and involved with healthy cholesterol function. makes ovarian cancer cells¹¹ more susceptible to death from chemo drugs.  We are seeing more and more that many nutrients can drastically improve the ability of chemo drugs to work better – and these studies are several more examples of this helpful function.

Collectively all of this science shows that the polymethoxyflavones nobiletin Type of citrus bioflavonoid shown to have anti-inflammatory, anti-oxidant, and blood sugar support properties. and tangeretin Special type of citrus bioflavonoid shown to reduce the risk for certin cancers, protecting nerve cells, and involved with healthy cholesterol function. are highly protective to your body in multiple ways and act to help our metabolize cholesterol and blood sugar, resulting in better leptin function and improved fat fitness – which is fundamental to a higher level of cardiovascular health.