Bone Health Opens a New Door to Blood Sugar Metabolism

It was surprising enough when fat was found making various hormones like leptin and adiponectin Protein hormone that modulates metabolism including glucose and fatty acid catabolism. High levels are associated with low body fat. and thus became an endocrine organ (hormone secreting).  It is now time to add bones to the list of endocrine organs that have a major influence on the metabolism of calories.  The new discoveries have immediate implications for improved bone health, improved blood sugar levels, and weight management.

Bone building cells are called osteoblasts.  Boosting the healthy function of osteoblasts is very important to bone health¹.  Osteoblasts also secrete a compound called osteocalcin Hormone secreted by osteoblasts for the bone formation process. It is also involved with pancreatic and insulin function and adiponectin secretion., which had mostly been thought to assist bone mineralization.

In August researchers made a major discovery and were able to prove that osteocalcin Hormone secreted by osteoblasts for the bone formation process. It is also involved with pancreatic and insulin function and adiponectin secretion. acted as a hormone communicating directly to the pancreas and to stored fat.  The researchers found that osteocalcin Hormone secreted by osteoblasts for the bone formation process. It is also involved with pancreatic and insulin function and adiponectin secretion.-deficient mice became obese and diabetic – even on a normal diet.  Conversely, when the osteocalcin Hormone secreted by osteoblasts for the bone formation process. It is also involved with pancreatic and insulin function and adiponectin secretion. levels were high then blood sugar levels were normal² and the mice did not gain weight even when overeating.

This research is the first to point out that osteocalcin Hormone secreted by osteoblasts for the bone formation process. It is also involved with pancreatic and insulin function and adiponectin secretion. is required for normal insulin function for a variety of reasons.  In the obese situation, fat cells make too much leptin and consequently the high leptin depresses adiponectin Protein hormone that modulates metabolism including glucose and fatty acid catabolism. High levels are associated with low body fat. .  Adiponectin is needed to make insulin work properly and prevent insulin resistance.  As it turns out, osteocalcin Hormone secreted by osteoblasts for the bone formation process. It is also involved with pancreatic and insulin function and adiponectin secretion. directly stimulates the production of adiponectin Protein hormone that modulates metabolism including glucose and fatty acid catabolism. High levels are associated with low body fat. in fat cells and insulin in the pancreas.  In turn, adiponectin Protein hormone that modulates metabolism including glucose and fatty acid catabolism. High levels are associated with low body fat. then stimulates osteoblasts to make osteocalcin Hormone secreted by osteoblasts for the bone formation process. It is also involved with pancreatic and insulin function and adiponectin secretion. – a mutually supportive network that promotes health.  This means that bones are a major player in blood sugar metabolism and proper bone health is needed to prevent diabetes.

On the flip side, as blood sugar rises and caramelization damage begins to build up (advanced glycation end products or AGES), then osteoblast function is clogged and osteocalcin Hormone secreted by osteoblasts for the bone formation process. It is also involved with pancreatic and insulin function and adiponectin secretion. in reduced³, leading directly to worsening health.

This new relationship between bones, stored fat, and the pancreas is an important link in preventing diabetes and solving the problem in those who have it.  This is because once a problem is in motion all aspects of the problem make each other worse (bone health, obesity, and blood sugar).  On the other hand, boosting bone health has a direct benefit to glucose metabolism.  Improving glucose metabolism by following the Leptin Diet and consistently exercising has a direct benefit to boosting bones.  Dietary supplements that support a specific topic such as bone health, blood sugar metabolism, or weight management are likely to be helpful for all three topics.  Fascinating to say the least.