Tocotrienols – A Multi-Dimensional Nutrient Powerhouse

Monday, February 25, 2013
By: Byron J. Richards,
Board Certified Clinical Nutritionist
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Tocotrienols should be a main part of any person’s dietary supplement program. Not only do they offer superior antioxidant protection, but they also work in numerous other ways to provide powerful health protection1 – especially to your brain and circulatory system. 

The tocotrienol form of vitamin E is far different than the common vitamin E, known as d alpha tocopherol. This is because common d alpha tocopherol, which is an excellent antioxidant, is limited in its function by a “long stiff tail.” In comparison, tocotrienols have a “short flexible tail” that is highly interactive with cell membranes; it enables them to provide superior protection to all cells in your body.

A number of studies have shown that this makes a dramatic difference in your nervous system and brain2 cells, by offering protection that is not provided by common vitamin E. Nerve-related wear and tear has various forms ranging in nature from poor stress tolerance, memory loss, and poor mental skills to more advanced nerve-related wear and tear that occurs as a person ages. Whether small or large, conditions of nerve wear and tear typically involve excessive neuro-excitation that heats up nerves and weakens them.  This leads to eventual nerve decay and destruction as the wear and tear trend continues over time. 

Primary causes of such problems include exposure to any city’s general pollution, acute chemical exposure, excess stress, and chemicals the FDA allows in the food supply (MSG, aspartame, food coloring, pesticides, and more). All of these forms of nerve irritation induce what is known as glutamate-driven excitotoxic damage. As it turns out, alpha tocotrienol can completely prevent this common and typical form of nerve damage that otherwise drives the nerve decay process. There is no natural molecule more effective than tocotrienols in this regard.

Studies with tocotrienols show that they readily cross the blood brain barrier and protect your nerves. They also have a high ability to accumulate in all vital organs – lending an unparalleled degree of nutritional support and protection. It is important to maintain regular supplementation3 of doses ranging from 35 mg to 300 mg per day, depending on the degree of support desired. Higher amounts offer more protection. If supplementation is discontinued the extra cellular protection is lost within several months.

In addition to extraordinary nerve and brain protection, tocotrienols are natural regulators of many aspects of health. Unlike common vitamin E, studies show that tocotrienols:

1) Protect against prostate4 and breast cancer5.

2) Activate p53 genes6, which are regulators of the cell cycle and the guardians of the human genome against cancer.

3) Turn down the master inflammatory switch known as NF-kappaB7, which is also a central problem in the growth of all types of cancer.

4) Prevent improper blood flow8 to tumors, in diabetics, and during arthritis.

5) Stop cell adhesion molecules9 that are needed to attach cholesterol into plaque, resulting in hardened and clogged arteries.

6) Naturally regulate the synthesis of cholesterol, helping lower high cholesterol10.

7) Are touted by scientists as one of the best all-purpose cardiovascular nutrients11, also protecting the heart and supporting healthy heart rhythms.

Any drug that could do 20 percent of what tocotrienols do would be the best selling drug in the world. And there are no adverse side effects.


Referenced Studies:
  1. ^ Tocotrienols in Disease Prevention  J Biol Chem.  Yoshida Y, Saito Y, Jones LS, Shigeri Y.
  2. ^ Potent Nerve Protection by Tocotrienols  J Neurochem.  Khanna S, Roy S, Parinandi NL, Maurer M, Sen CK.
  3. ^ Consistent Tocotrienol Supplementation is Best for Maintaining Health   Free Radic Res.  Patel V, Khanna S, Roy S, Ezziddin O, Sen CK.
  4. ^ Tocotrienols and Prostate Cancer  Biochem Biophys Res Commun.  Srivastava JK, Gupta S.
  5. ^ Tocotrienols and Breast Cancer  Asia Pac J Clin Nutr.  Nesaretnam K, Gomez PA, Selvaduray KR, Razak GA.
  6. ^ Tocotrienols and General Cancer Protection  Cell Cycle.   Agarwal MK, Agarwal ML, Athar M, Gupta S.
  7. ^ Tocotreinols Turn Down Excess NF-KappaB   J Biol Chem.  Ahn KS, Sethi G, Krishnan K, Aggarwal BB.
  8. ^ Proper Circulation Supported by Tocotrienols  J Nutr.  Nakagawa K, Shibata A, Yamashita S, Tsuzuki T, Kariya J, Oikawa S, Miyazawa T.
  9. ^ Tocotrienols Help Prevent Atherosclerosis  Atherosclerosis.   Theriault A, Chao JT, Gapor A.
  10. ^ Tocotrienols Lower Cholesterol  Atherosclerosis.  Baliarsingh S, Beg ZH, Ahmad J.
  11. ^ Tocotrienols in cardioprotection.  Vitam Horm.  Das S, Nesaretnam K, Das DK.

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