Vitamin D and Hyperthyroid

Byron's Comments:

Many chemicals irritate your thyroid and provoke an immune reaction. A lack of vitamin D appears to make this reaction worse and may result in autoimmune hyperthyroid problems.

Study Title:

Vitamin D deficiency modulates Graves' hyperthyroidism induced in BALB/c mice by thyrotropin receptor immunization.

Study Abstract:

Thyrotropin receptor (TSHR) antibodies and hyperthyroidism are induced by immunizing mice with adenovirus encoding the TSHR or it’s A-subunit. Depleting regulatory T cells (Treg) exacerbates thyrotoxicosis in susceptible BALB/c, and induces hyperthyroidism in normally resistant C57BL/6, mice. Vitamin D plays an important role in immunity: high dietary vitamin D intake suppresses (and low intake enhances) adaptive immune responses. Vitamin D induced immunosuppression may enhance Treg. Therefore, we hypothesized that decreased vitamin D intake would mimic Treg depletion and enhance hyperthyroidism induced by A-subunit adenovirus immunization. BALB/c mice had a reduced ability versus C57BL/6 mice to generate the active metabolite of vitamin D [1,25(OD)2D3 ]. Vitamin D deficiency induced subtle immune changes in BALB/c (not C57BL/6) mice. Compared with mice fed regular chow, vitamin D deprived BALB/c had fewer splenic B cells, decreased IFN- responses to mitogen, and lacked memory T cell responses to A-subunit protein. However, vitamin D deficiency did not alter TSHR antibody responses measured by ELISA, TSH binding inhibition or cAMP generation from TSHR-expressing cells. Unexpectedly, compared with vitamin D-sufficient mice, vitamin D-deficient BALB/c mice had lower pre-immunization thyroxine levels and developed persistent hyperthyroidism. This difference was unrelated to the immunological changes between vitamin D deficient - or sufficient- animals. Previously, we found that different chromosomes or loci confer susceptibility to TSHR antibody induction versus thyroid function. Our present studies provide evidence that an environmental factor, vitamin D, has only minor effects on induced immunity to the TSHR, but directly affects thyroid function in mice.

From press release:
Vitamin D may directly affect thyroid function, according to research in a preclinical animal model published online Oct. 16 in Endocrinology.

Alexander Misharin of the UCLA School of Medicine in Los Angeles and colleagues tested the role of vitamin D in a mouse model of Graves’ disease, in which hyperthyroidism is induced by immunization with an adenovirus encoding the thyrotropin receptor. Because it was previously established that vitamin D enhances regulatory T cells, the authors hypothesized that decreasing vitamin D through a controlled diet would intensify the severity of Graves’ disease in the model.

Vitamin D deficiency induced only small immunological changes. Unexpectedly, the vitamin D-deprived mice developed persistent hyperthyroidism following immunization, unlike their vitamin D-sufficient matched controls. This disparity was not explained by any immunological difference, and the authors speculated that the persistent hyperthyroidism was instead caused by an increased sensitivity of the thyroid to the antibodies directed against thyrotropin.

“Rather than affecting the immune response, the most important effect of vitamin D deficiency was on the thyroid,” the authors write, providing evidence for the role of an environmental factor, vitamin D, on thyroid function.

Study Information:

Alexander Misharin, Martin Hewison, Chun-Rong Chen, Venu Lagishetty, Holly A. Aliesky, Yumiko Mizutori, Basil Rapoport, and Sandra M. McLachlan. Vitamin D deficiency modulates Graves' hyperthyroidism induced in BALB/c mice by thyrotropin receptor immunization. Endocrinology. 2008 October 
Autoimmune Disease Unit, Cedars-Sinai Research Institute and UCLA School of Medicine, 8700 Beverly Blvd, Suite B-131, Los Angeles, CA.

Related Entries: Master Enzyme Switch Deactivated In Chronic Fatigue Syndrome and Fibromyalgia
Cinnamon Provides Impressive Benefits for Blood Sugar, Heart Health, Inflammation and More
Gastric Bypass Nutritional Consequences
Toxic Mineral Linked with Bowel Inflammation, Mitochondrial Damage, and Alzheimer’s
Magnesium and Vitamin B1 - Team Players Needed for Brain, Muscles, Metabolism, and More
Vitamin B1 / Thiamin - Are you getting enough?
H. Pylori and Autoimmune Link
Common Medications That Rob the Body of Nutrients
The Many Faces of Gluten Intolerance
Supplement Quality - Are You Getting What’s On the Label?
Statin Drugs Cause Atherosclerosis and Heart Failure
Heart Disease and Depression: A Two Way Street
Broken Heart Syndrome
Ten Things that Interfere with Thyroid Function
Vaccine Injury with Chronic Fatigue Syndrome and Fibromyalgia
Bone Loss Caused by Thyroid Meds and Other Drugs
Five Key Tips for a Healthy 2015
Top Health Stories of 2014
Combat the Winter Blues
Carnosine – Amazing Benefits for Athletes, Heart, Brain, Eyes, and Diabetes
ADT Prostate Cancer Therapy Does More Harm Than Good
Musicians: A Note on Taking Care of the Body
Infections Linked to Autoimmune Thyroid Problems
Noni: Tropical Super Fruit – Powerful Support for the Immune System, Brain, Bones, and more
Enlarged Adenoids Linked with Food Allergies
Combat Ear Infections and Congestion Naturally
Glaucoma: Protecting Against a Silent, Devastating Disorder
Protect and Energize Your Immune System
GMOs, Roundup, and Sunscreen Linked with Diminished Brain Resiliency
Signs of Concussions and Mild Traumatic Brain Injury
Sleep – Molecular Clean Up Time for the Brain
Artificial Sweeteners Provoke High Risk for Diabetes
Hypothyroidism, Brain Stress, and Season Changes
Alcohol, Adolescents, and Young Adults – A Neurological Disaster Waiting to Happen
GABA: Managing Brain Stimulation, Anxiety, and Other Consequences
Brain Fatigue: Fundamental Solutions
Brain Fatigue 101
Astonishing Benefits of Cranberries
Summer Heat Stress – More Than Just Dehydration
Chronic Active Epstein Barr Virus: Additional Tools for the Battle
Pine Nut Oil Reduces Inflammation, Clotting Risk, and Fatty Liver Congestion
New Findings with Epstein Barr Virus: The Sleeping Giant
Type 1 Diabetes: Risk Factor Alert
Disrupted Gut Clocks Linked with IBS, GERD, Obesity, and Other GI Concerns
Body Clocks and Weight Management – It’s All About Timing
Saturated Fat Myth – Debunked Again
Powerful Nutrition for Common Chemical Exposures
Endocrine Disruptor Compounds and Natural Solutions
Endocrine Disruptor Compounds and Your Hormones
Low Blood Pressure Linked with Brain Atrophy
Vitamin K, Leptin, AGEs, and Arthritis
Advanced Solutions for Osteoarthritis
Osteoarthritis: Good Oils versus Bad Oils and Inflammation
High Levels of Omega 6 Fatty Acids Found in Bones of Osteoarthritis Patients Worsens Joint Breakdown
Lipoic Acid Protects the Heart and Immune System from Acute Emotional Stress
Whiplash, Thyroid, and Adrenals
Brain Inflammation Now Documented in Chronic Fatigue Syndrome
Brain Protective Effects of Proathocyanidins
Nutrient Highlight: Discover the Best Form of Folate
Lutein and Zeaxanthin Offset Gene Weaknesses that Cause Macular Degeneration
Lycopene Builds Its Anti-Prostate Cancer Case
Carotenes Improve the Quality of Semen
Vitamin B12 as Methylcobalamin Repairs Nerves & Lowers Pain
Folic Acid Activates Neural Stem Cells for Brain Rejuvenation
Chromium Improves Insulin Function & Reduces Binge Eating
How Fiber and Niacin Protect Against Colon Inflammation and Cancer
Berries Have Anti-Aging Impact on Immune System
Strawberries Reduce Cardiovascular Risk
Friendly Flora Improves Fatty Liver Disease
Flavonoid Intake Improves Cardio Health in At-Risk Men
Polyphenols and Essential Fatty Acids Reduce Cardio Risk in Overweight People
Vitamin C Reduces the Risk for Hemorrhagic Stroke
Testosterone Therapy Increases Heart Attack Risk
Magnesium Intake Linked to Lower Cardiovascular Inflammation
Q10 Boosts Energy, Nerves, Muscles & Metabolism
Coenzyme Q10 Remarkably Improves Circulation
Tyrosine Helps Maintain Mental Ability Under Stress
Green Tea Extract Lowers Blood Pressure, Cholesterol, Blood Sugar & Inflammation
Poor Flexibility is a Sign of Stiff Arteries
A Sluggish Lymph System Causes Snoring & Sleep Apnea
DHA is Vital to Cardiovascular Wellness
Magnesium Supplements Lower Blood Pressure, Prevent Calcification
Magnesium for the Prevention of Heart Disease
Pomegranate Protects HDL Cholesterol from Damage
Pomegranate Blocks Flu Replication
Tocotrienols:  Twenty Years of Dazzling Cardiovascular and Cancer Research
Is Resveratrol the Fountain of Youth?
Grape Seed Extract Lowers Blood Pressure
Scientists Tout Resveratrol as a Primary Nutrient for Cardio Health
Leptin, Thyroid, and Weight Loss

Most Popular News:

Connect with Wellness Resources:

Connect on Facebook Follow us on Twitter Wellness Resources on Pinterest Wellness Resources YouTube Channel Get RSS News Feeds
Thyroid and Metabolism