The Treatment of Osteoporosis with Calcium Fructoborate

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Calcium fructoborate has a favorable impact on pain and calcium dynamics in patients with osteoporosis.

Study Title:

The Treatment of Osteoporosis with Calcium Fructo-Borate

Study Abstract:

Osteoporosis is a disease which inflicts large groups of people, of different ages, both male and female, and requires a long period of treatment, with high costs, both material and social. Through its complications, the disease produces a large number of patients who are immobilized in bed and also patients with multiple handicaps. The treatment of osteoporosis is expensive and very long. Considering the fact that the most affected are the second and third age groups, which also have limited financial resources because of the small pension they receive and also because of the decreased work capacity, while studying the effects of the boron through its derived compounds on osteoporosis, many authors have reached the conclusion that it can be successfully used in the economical treatment of this disease. The hormonal treatment and the calcium replacement were admitted to be out of reach for a person with an advanced osteolocomotive handicap.

On initiative of S.C. Natural Research S.R.L. Craiova, represented by the Professor Doctor Biochemist Romulus Scorei, a program of clinical and practical research of the effects of the Calcium Fructo-Borate on osteoporosis was initiated, using this drug as an adjuvant in alimentation, thus creating the Fortex Margarine, a product approved by the Romanian Ministry of health. The Fortex Margarine is no different from any ordinary margarine, except for the fact that it contains 125 mg of active substance, represented by the Calcium Fructo-Borate for every 250 (300 g) of product. The contract signed between the producer and us was done in order to verify the positive effect of the Calcium Fructo-Borate administered as a nutritional supplement in the treatment of osteoporosis. The duration of the project is to be of 3, 6 months, with a base group of 100 patients who have had osteoporosis, as a disease, clinically and para-clinically diagnosed. The optimal criteria of diagnosis used to determine the study-group was the ecographic bone osteotomodensimetry. The device used was an osteodensimeter, of the osteospace MediLink type, of the latest generation with very good viability and precision….

In our study we used a heterogeneous group of 100 people, (men and women) randomly, divided in age groups that showed a preponderance of the osteoporosis at the ages of over 40, especially in the female population. This can be related to the presence of
the physiological climax, as it is known that it induces very severe hormonal modifications in the endocrine constellation of females, leading to major unbalances of the metabolism generally and to the phosphor-calcium metabolism in particular….

The conclusions we have drawn from here are guide-lines for the accurate appreciation of the efficiency of the treatment we have applied. We have mentioned earlier that the first sign of improvement noted, starting with the 21st day of treatment, was the reduction, in a significant degree, of the osteocope pain, a profound pain with an almost continuous character, exacerbated during the night by walking and prolonged orthostaticy.

The osteocope pain is produced by the de-calcification of the bones, a soft bone being a painful bone. This means that the bone proteic matrix, spoiled of the calcium, begins to impregnate itself with calcium. Starting with week four, five, besides the significant reduction or even disappearance of the pain, we can notice the reduction of the articular discomfort, with a decrease of the articular pain, a fact that leads implicitly to the increase of the articular movement abilities and indirectly to the increase of the effort capacities. This fact was noticed in most of the patients (over 68% of them), which is an extremely important achievement….

The increase of the blood calcium level was present on almost all the persons participating in the study. From here we drew the conclusion that a first effect of administering the Calcium Fructo-Borate is that of increasing the level of the blood calcium, making that possible either by an increased absorption of the ionized calcium, or by a better management of the calcium deposits, using other ions as alternatives (Mg, Cu, Mn).

The increase of the blood calcium level then leads implicitly, through a feed-back phenomenon, to the introduction of the calcium in the deposit (meaning the bone), that most likely being the key that leads to the decrease of the pains. Studies done by other authors, Newhame, followed by Bellamy, show that the articular discomfort is caused by the intimate mechanism of rebuilding of the articular cartilages, through the action of the Calcium Fructo-Borate on the condroitinsulfates through colecalciferol, these being the “bricks” of the cartilage. The reconstruction of the 83% Increase of the blood calcium level after 30 days of treatment articular cartilage leads implicitly to a decrease of the articular pain and to the secondary articular dejects, thus increasing the amplitude of the articular movements…

At the end of the three months (actually, because of the wide area inhabited by the persons participating in the study, and due to the difficulty in addressing them, it lasted almost six months), we did laboratory analysis of all the participants (blood calcium level)
and we determined the osteodensiometrical curve.  In over 66% of the case the curve has a positive rise, associated with the relative symptomatology. 28 % of the patients showed a stop of the curve, but with positive symptomatology, and the remaining 6% had an aggravation of the curve, with a negative evolution both of the curve and of the symptoms.

Study Information:

V. Ghivercea, D. Grecu, Corina Lichiardopol, R. Maria. The Treatment of Osteoporosis with Calcium Fructo-Borate ORTHOPEDICS AND TRAUMATOLOGY - ROMANIAN ORTHOPEDY AND TRAUMATOLOGY SOCIETY 2004 July Vol. 14, nr. 1-2, p. 1-132

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Thyroid and Metabolism