Resveratrol Protects Against High Fat Diet, Improves Insulin Resistance

Byron's Comments:

The problem for Big Pharma is that plain resveratrol from nature is likely to be far more effective at supporting human health than something Big Pharma concocts. Thus, they will walk the bizzare line of trying to negate resveratrol dietary supplements while promoting a pharmaceutical brand.

Study Title:

Sirtuins: novel targets for metabolic disease in drug development.

Study Abstract:

Calorie restriction extends lifespan and produces a metabolic profile desirable for treating diseases such as type 2 diabetes. SIRT1, an NAD(+)-dependent deacetylase, is a principal modulator of pathways downstream of calorie restriction that produces beneficial effects on glucose homeostasis and insulin sensitivity. Activation of SIRT1 leads to enhanced activity of multiple proteins, including peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) and FOXO which helps to mediate some of the in vitro and in vivo effects of sirtuins. Resveratrol, a polyphenolic SIRT1 activator, mimics the effects of calorie restriction in lower organisms and in mice fed a high-fat diet ameliorates insulin resistance. In this review, we summarize recent research advances in unveiling the molecular mechanisms that underpin sirtuin as therapeutic candidates and discuss the possibility of using resveratrol as potential drug for treatment of diabetes.

Study Information:

Jiang WJ. Sirtuins: novel targets for metabolic disease in drug development. Biochem Biophys Res Commun.  2008 August  29;373(3):341-4.

Related Entries: Resveratrol Helps Improve the Fitness of Your Fat

My cart is empty.   View Cart |  Login

• How Protein Helps Weight Loss
  
• The Five Rules of The Leptin Diet
  
• The Facts on Magnesium Stearate
  
• What is Leptin?
  
• Taking Q10 for a Test Drive – Is Ubiquinol Better?