Quercetin and Blood Pressure

Byron's Comments:

Quercetin helps allergies and inflammation, this shows how it helps blood pressure.

Study Title:

Pure dietary flavonoids quercetin and (–)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men.

Study Abstract:

Background: Dietary flavonoids may improve endothelial function and ultimately lead to beneficial cardiovascular effects.

Objective: The objective was to assess whether pure dietary flavonoids can modulate nitric oxide and endothelin-1 production and thereby improve endothelial function.

Design: A randomized, placebo-controlled, crossover trial in 12 healthy men was conducted to compare the acute effects of the oral administration of 200 mg quercetin, (–)-epicatechin, or epigallocatechin gallate on nitric oxide, endothelin-1, and oxidative stress after nitric oxide production was assessed via the measurement of plasma S-nitrosothiols and plasma and urinary nitrite and nitrate concentrations. The effects on oxidative stress were assessed by measuring plasma and urinary F2-isoprostanes. Plasma and urinary concentrations of quercetin, (–)-epicatechin, and epigallocatechin gallate were measured to establish the absorption of these flavonoids.

Results: Relative to water (control), quercetin and (–)-epicatechin resulted in a significant increase in plasma S-nitrosothiols, plasma nitrite, and urinary nitrate concentrations (P < 0.05), but not in plasma nitrate or urinary nitrite. Epigallocatechin gallate did not alter any of the measures of nitric oxide production. Quercetin and (–)-epicatechin resulted in a significant reduction in plasma endothelin-1 concentration (P < 0.05), but only quercetin significantly decreased the urinary endothelin-1 concentration. None of the 3 treatments significantly changed plasma or urinary F2-isoprostane concentrations. Significant increases in the circulating concentrations of the 3 flavonoids were observed (P < 0.05) after the corresponding treatment.

Conclusions: Dietary flavonoids, such as quercetin and (–)-epicatechin, can augment nitric oxide status and reduce endothelin-1 concentrations and may thereby improve endothelial function

Study Information:

Wai Mun Loke, Jonathan M Hodgson, Julie M Proudfoot, Allan J McKinley, Ian B Puddey and Kevin D Croft  Pure dietary flavonoids quercetin and (–)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men. American Journal of Clinical Nutrition 2008 October Vol. 88, No. 4, 1018-1025.
School of Medicine and Pharmacology (WML, JMH, JMP, IBP, and KDC) and the School of Biomedical, Biomolecular and Chemical Sciences (WML and AJM), University of Western Australia, Perth, Western Australia



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