Oxytocin Modulates Appetite

Byron's Comments:

Oxytocin is a stress-eating buffer, helping to prevent normal stomach hunger from going out of control in your brain.

Study Title:

Oxytocin inhibits the stimulatory effect of ghrelin on circulating neuropeptide Y levels in humans.

Study Abstract:

Oxytocin (OT) effect on ghrelin-stimulated neuropeptide Y (NPY) secretion was evaluated in 12 normal men. Tests: ghrelin (1 mug/kg B.W. as an intravenous bolus); OT (2 mIU/min infusion); ghrelin plus OT; normal saline. Plasma NPY did not change during saline or OT infusions, whereas it showed a significant 29% increase vs baseline at 15 min after ghrelin injection. When OT was present, ghrelin-induced NPY increment was completely abolished. Results show that oxytocin modulates the NPY response to ghrelin, whereas it is unable to produce direct inhibitions of basal circulating NPY levels.

Study Information:

Oxytocin inhibits the stimulatory effect of ghrelin on circulating neuropeptide Y levels in humans.Coiro V, Saccani-Jotti G, Rubino P, Manfredi G, Vacca P, Volta E, Chiodera P. Oxytocin inhibits the stimulatory effect of ghrelin on circulating neuropeptide Y levels in humans. J Neural Transm.  2008 May  Epub ahead of print.
Department of Internal Medicine and Biomedical Sciences, University of Parma, Via A. Gramsci, 14-43100, Parma, Italy.

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