Leptin and Thyroid Cancer

Byron's Comments:

The data is becoming clearer that leptin problems cause thyroid cancer.

Study Title:

Role of leptin and its receptors in the pathogenesis of thyroid cancer

Study Abstract:

Leptin is a multifunctional adipose-derived cytokines that play a critical role in bodyweight homeostasis and energy balance. Recently, leptin and leptin receptor dysreulation have been reported in variety of malignant cells including thyroid. Leptin modulates growth and proliferation of cancer cells via activation of various growth and survival signaling pathways including JAK/STAT, PI3-kinase/AKT and/or Map kinases. In this review, current understanding of leptin’s role in the pathogenesis of thyroid cancer has been described.

Study Information:

Uddin S, Hussain AR, Siraj AK, Khan OS, Bavi PP, Al-Kuraya KS Role of leptin and its receptors in the pathogenesis of thyroid cancer Int J Clin Exp Pathol.  2011 October  ;4(7):637-43.
Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center Riyadh, Saudi Arabia.

Full Study:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209603/?tool=pubmed

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