Friendly Flora Inhibits Toxin Release by E. Coli
Another angle on the beneficial help of friendly flora to combat infectious E. coli.
Study Title:Probiotic inhibits the cytopathic effect induced by Escherichia coli O157:H7 in Vero cell line model.
AIMS: The effectiveness of four strains of Bifidobacteria against enterohemorrhagic Escherichia coli O157:H7 infection was studied using a Vero cell model.
METHODS AND RESULTS: E. coli O157 was inoculated on the Vero cell line before and after treatment with probiotic. The cytopathic effect (CPE) was evaluated during 24 h of incubation. The results indicated that Shiga toxin activity was inhibited by the probiotic. To prevent a Stx2 CPE, the probiotic needs one log more than the Stx1.
CONCLUSION: The Vero cell assay, in particular, is a good model to evaluate the effect of Bifidobacteria inhibiting bacterial attachment because of soluble substances and the competitive aspect and could be used in a variety of foods like milk and yoghurt to protect pathogen bacteria.
SIGNIFICANCE AND IMPACT OF THE STUDY: Probiotics could control pathogenic bacteria and Vero cell introduce as a model for evaluation of probiotics against pathogen bacteria.
Tahamtan Y, Kargar M, Namdar N, Rahimian A, Hayati M, Namavari MM. Probiotic inhibits the cytopathic effect induced by Escherichia coli O157:H7 in Vero cell line model. Lett Appl Microbiol. 2011 May 52(5):527-31.
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