Flavonoid in Hawthorn Acts as Natural ACE Inhibitor

Byron's Comments:

This study indicates one way that hawthorn may help relax your vascular system. The Chinese herb in this study is a wild rhubarb, although this study is widely quoted for a benefit of hawthorn as the active component tested is in both herbs.

Study Title:

Inhibitory Effects of Condensed Tannins on Angiotensin Converting Enzyme.

Study Abstract:

Effects of condensed tannins isolated from Rhei Rhizoma on the activities of angiotensin converting enzyme (ACE) and various proteases were examined in vitro. Among the various condensed tannins tested, procyanidin B-5 3, 3’ di-O-gallate and procyanidin C-1 3, 3’, 3’‘-tri-O-gallate strongly inhibited the activity of ACE. The concentration of procyanidin B-5 3, 3’-di-O-gallate required for 50% inhibition of ACE was 1.3×10-6 M. The inhibition of ACE by condensed tannins was reversible and non-competitive, according to dialysis and to Dixon plots. However, over one hundred times the concentration was required to inhibit activities of other proteases such as trypsin, chymotrypsin, leucine aminopeptidase, carboxypeptidase A and urinary kallikrein. These results suggest that the inhibitory effects of condensed tannins on the activities of ACE are specific.

Study Information:

Shinji UCHIDA, Nobuhiko IKARI, Hisashi OHTA2, Masami NIWA, Gen-ichiro NONAKA, Itsuo NISHIOKA and Masayori OZAKI.  Inhibitory Effects of Condensed Tannins on Angiotensin Converting Enzyme. The Japanese Journal of Pharmacology. 1987 April Vol.43 , No.2, pp.242-246.

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Thyroid and Metabolism