Vitamin C and Lipoic Acid Protect Eyes

Byron's Comments:

Antioxidants are highly protective to free-radical induced eye stress (which is common in just about everyone - especially those with blue eyes).

Study Title:

Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization-associated oxidative stress.

Study Abstract:

In several disease states, abnormal growth of blood vessels is associated with local neuronal degeneration. This is particularly true in ocular diseases such as retinal angiomatous proliferation (RAP) and macular telangiectasia (MacTel), in which, despite the absence of large-scale leakage or hemorrhage, abnormal neovascularization (NV) is associated with local neuronal dysfunction. We describe here a retinal phenotype in mice with dysfunctional receptors for VLDL (Vldlr–/– mice) that closely resembles human retinal diseases in which abnormal intra- and subretinal NV is associated with photoreceptor cell death. Such cell death was evidenced by decreased cone and, to a lesser extent, rod opsin expression and abnormal electroretinograms. Cell death in the region of intraretinal vascular abnormalities was associated with an increased presence of markers associated with oxidative stress. Oral antioxidant supplementation protected against photoreceptor degeneration and preserved retinal function, despite the continued presence of abnormal intra- and subretinal vessels. What we believe to be novel, Müller cell–based, virally mediated delivery of neurotrophic compounds specifically to sites of NV was also neuroprotective. These observations demonstrate that neuronal loss secondary to NV can be prevented by the use of simple antioxidant dietary measures or cell-based delivery of neurotrophic factors, even when the underlying vascular phenotype is not altered.

Study Information:

Michael I. Dorrell, Edith Aguilar, Ruth Jacobson, Oscar Yanes, Ray Gariano, John Heckenlively, Eyal Banin, G. Anthony Ramirez, Mehdi Gasmi, Alan Bird, Gary Siuzdak and Martin Friedlander. Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization-associated oxidative stress. J. Clin. Invest. 2009 February
Department of Cell Biology and Department of Molecular Biology, Scripps Center for Mass Spectrometry, The Scripps Research Institute, La Jolla, California, USA.

Full Study:

http://www.jci.org/articles/view/35977

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