Too Much Fat Drives Inflammatory Disease

Byron's Comments:

Because stored fat naturally contains a lot of immune cells, these are capable of generating excess inappropriate inflammation, which they do when a person is overweight. This problem acts as stress to your body and contributes in a major way to the decline of health and onset of disease.

Study Title:

Adipokines in diabetes and cardiovascular diseases.

Study Abstract:

Recent studies suggest that adipocyte-secreted factors called adipokines are involved in obesity-associated complications including hyperlipidemia, diabetes mellitus, arterial hypertension, atherosclerosis, and heart failure. Among those, adiponectin is an antidiabetic and antiatherogenic protein, concentrations of which are decreased in obesity-associated metabolic and vascular disorders. In contrast, leptin, tumor necrosis factor a, interleukin-6, monocyte chemoattractant protein-1, and plasminogen activator inhibitor-1 are upregulated in obesity and contribute to the development of diabetes and vascular disease. In this review, the relevance of adipokines in obesity, insulin resistance, diabetes mellitus, atherosclerosis, and cardiovascular diseases is discussed.

Study Information:

Kralisch S, Sommer G, Deckert CM, Linke A, Bluher M, Stumvoll M, Fasshauer M. Adipokines in diabetes and cardiovascular diseases. Minerva Endocrinol.  2007 September  32(3):161-71
Department of Internal Medicine III, University of Leipzig, Leipzig, Germany.

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