Sodium-Potassium Pump in Low-Renin Hypertension

Byron's Comments:

Lots of blood pressure problems could be solved simply by taking potassium and reducing sodium.

Study Title:

Sodium-Potassium Pump in Low-Renin Hypertension

Study Abstract:

Recent studies suggest that sodium-dependent low-renin hypertension in animals results at least in part from sodium-potassium pump inhibition in blood vessels and heart by a humoral agent released from or influenced by the anteroventral third ventricular area of the brain. For example, a high salt intake in a rat with reduced renal mass results in the appearance of a heat-stable sodium pump inhibitor in the plasma, decreased cardiac Na+, K+-ATPase activity, decreased arterial sodium-potassium pump activity, and hypertension. These changes are reversed by reducing the salt intake or by producing a lesion in the anteroventral third ventricular area of the brain. The course of the development of pump inhibition is similar to the course of the development of hypertension. Sodium-potassium pump inhibition by a humoral agent may also occur in humans with low-renin hypertension. A high potassium intake may stimulate pump activity.

Study Information:

FRANCIS J. HADDY Sodium-Potassium Pump in Low-Renin Hypertension Ann Intern Med   1983 May  vol. 98 no. 5 Part 2 781-784.
Department of Physiology, Uniformed Services University; Bethesda, Maryland.

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