Herpes Simplex Virus Inactivated By Silver

Byron's Comments:

In this study silver did not prevent the virus from binding, rather, it rendered it ineffective once it did bind to a cell.

Study Title:

Specific Inactivation of Herpes Simplex Virus by Silver Nitrate at Low Concentrations and Biological Activities of the Inactivated Virus

Study Abstract:

The infectivities of herpes simplex virus types 1 and 2 were inactivated by silver nitrate at concentrations of 30 μM or less, which did not affect at all the infectivities of hemagglutinating virus of Japan, vesicular stomatitis virus, poliovirus, vaccinia virus, and adenovirus. The inactivated virus retained the capability of adsorbing to the cell, with an adsorption kinetics quite similar to that of intact virus, and of inducing the concanavalin A agglutinability in the infected cells, whereas it lost completely the capability of producing viral antigens and other cytopathic changes.

Study Information:

Fumio Shimizu, Yoshinobu Shimizu, and Katsuo Kumagai Specific Inactivation of Herpes Simplex Virus by Silver Nitrate at Low Concentrations and Biological Activities of the Inactivated Virus Antimicrob Agents Chemother  1976 July  10(1): 57–63.
Department of Microbiology, Tohoku University School of Dentistry, Sendai, Japan.

Full Study:

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=429689




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