Byron's Comments:

Carnosine helps to calm down excess sympathetic nerve activity that stresses the kidneys. Researchers believe this helps offset the stress of obesity and leptin resistance on the kidneys.

Study Title:

Effects of L-carnosine on renal sympathetic nerve activity and DOCA-salt hypertension in rats.

Study Abstract:

The effects of L-carnosine (beta-alanyl-L-histidine) on the neural activity of the renal sympathetic nerve and on DOCA-salt hypertension in rats were examined. Intravenous injection of 1 microg L-carnosine inhibited renal sympathetic nerve activity in urethane-anesthetized animals, and a diet containing 0.0001% or 0.001% L-carnosine decreased blood pressure elevation in DOCA-salt hypertensive rats. Since L-carnosine is mainly synthesized in the skeletal muscles of mammals, it is not unreasonable to postulate that L-carnosine is an endogenous factor controlling the blood pressure in a manner possibly antagonistic to the obesity-associated hypertensive effect of leptin.

Study Information:

Niijima A, Okui T, Matsumura Y, Yamano T, Tsuruoka N, Kiso Y, Nagai K.  Effects of L-carnosine on renal sympathetic nerve activity and DOCA-salt hypertension in rats.  Auton Neurosci.   2002 May  97(2): 99-102.
Niigata University School of Medicine, Asahimachidoori, Japan.

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Carnosine Helps Prevent Kidney Damage from Diabetes

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