Carbohydrates, Inflammatory Disease, and Mortality Risk

Byron's Comments:

High glycemic food intake is linked to an increased risk of inflammatory death.

Study Title:

Carbohydrate nutrition and inflammatory disease mortality in older adults

Study Abstract:

Background: Several studies suggest that carbohydrate nutrition is related to oxidative stress and inflammatory markers.

Objective: We examined whether dietary glycemic index (GI), dietary fiber, and carbohydrate-containing food groups were associated with the mortality attributable to noncardiovascular, noncancer inflammatory disease in an older Australian cohort.

Design: Analysis included 1490 postmenopausal women and 1245 men aged ge 49 y at baseline (1992–1994) from a population-based cohort who completed a validated food-frequency questionnaire. Cox proportional hazards ratios were calculated both for death from diseases in which inflammation or oxidative stress was a predominant contributor and for cardiovascular mortality.

Results: Over a 13-y period, 84 women and 86 men died of inflammatory diseases. Women in the highest GI tertile had a 2.9-fold increased risk of inflammatory death compared with women in the lowest GI tertile [multivariate hazard ratio in energy-adjusted tertile 3 (tertile 1 as reference): 2.89; 95% CI: 1.52, 5.51; P for trend: 0.0006, adjusted for age, smoking, diabetes, and alcohol and fiber consumption]. Increasing intakes of foods high in refined sugars or refined starches (P = 0.04) and decreasing intakes of bread and cereals (P = 0.008) or vegetables other than potatoes (P = 0.007) also independently predicted a greater risk, with subjectsrsquo GI partly explaining these associations. In men, only an increased consumption of fruit fiber (P = 0.005) and fruit (P = 0.04) conferred an independent decrease in risk of inflammatory death. No associations were observed with cardiovascular mortality.

Conclusion: These data provide new epidemiologic evidence of a potentially important link between GI and inflammatory disease mortality among older women.

Study Information:

Anette E Buyken, Victoria Flood, Marianne Empson, Elena Rochtchina, Alan W Barclay, Jennie Brand-Miller, and Paul Mitchell  Carbohydrate nutrition and inflammatory disease mortality in older adults  Am J Clin Nutr  2010 September 92: 634-643.
Research Institute of Child Nutrition, Rheinische Friedrich-Wilhelms-Universitaumlt Bonn, Dortmund, Germany.

Most Popular News:

Connect with Wellness Resources:

Connect on Facebook Follow us on Twitter Wellness Resources on Pinterest Wellness Resources YouTube Channel Get RSS News Feeds
Thyroid and Metabolism