2-Hydroxyestrone: The "Good" Estrogen

Byron's Comments:

Sending enough estrogen down this pathway reduces the risk for female cancers.

Study Title:

2-Hydroxyestrone: The "Good" Estrogen

Study Abstract:

The issue of the role of 2-hydroxyestrone (2-OHE1) in breast cancer has been the subject of considerable controversy as to whether it is carcinogenic or anticarcinogenic. The expanding data base outlined below is most consistent with the conclusion that 2-OHE1 is anticarcinogenic. In every experimental model in which 2-hydroxylation was increased, protection against tumors was achieved. Correspondingly, when 2-hydroxylation was decreased, an increase in cancer risk was observed. Even more dramatically, in the case of laryngeal papillomas induction of 2-hydroxylation with indole-3-carbinol (I3C) has resulted in inhibition of tumor growth during the time that the patients continue to take 13C or vegetables rich in this compound.

Study Information:

Bradlow HL, Telang NT, Sepkovic DW, Osborne MP. 2-Hydroxyestrone: The "Good" Estrogen J Endocrinol.   1996 September  150 Suppl:S259-65.
Strang Cancer Research Laboratory, New York, New York 10021, USA.

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