Earlier this year the New England Journal of Medicine and the New York Times reported on the fact that most of the unfavorable studies on SSRIs were never published, thus withholding the true picture that the medications hardly worked at all.  On top of that, drug companies such as Eli Lily withheld known suicide data (information that has been forced out in lawsuits).  There is a reason psychiatrists are bribed with more Big Pharma money than any other type of doctor.

Last year we found out that these SSRI drugs more than double the risk for fractures in anyone over the age of 50 who uses them regularly.  These bone-damaging effects of SSRIs have been confirmed by another very recent study.

In an unexpected finding from research not involving SSRIs, a new mechanism has been identified which explains why having high blood levels of serotonin is associated with increased bone loss.  The researchers found that too much serotonin directly interferes with how new bone is formed.

This new information also raises the possibility that those taking tryptophan supplements may also raise serotonin into the “bone loss” range.  Please note that Wellness Resources does not sell tryptophan because I have never felt it was the best way to boost and stabilize mood.

There are many nutrients that can help your mind as well as help your bones.  A good diet and regular exercise are the foundation for both mental and bone health.  There are no shortcuts to real health.

The FDA should warn all adults over 50 not to take anti-depressants unless there is simply no other way, as the bone loss risk is simply far too great. 

The researchers expanded on their earlier work with yeast and found that a novel mechanism also applies to mammals.  One of SIRT1’s duties is to stand guard over gene switches to ensure only those that are relevant to healthy function of that type of cell are activated.  When a cell is stressed by toxins, free radicals, germs, UV radiation, inflammation, or something else it can cause DNA damage.  Under these circumstances SIRT1 leaves its guard post and helps out with emergency DNA repair.  While SIRT1 is gone from guard duty genes can activate that should not, causing cell dysregulation and aging.  In a healthy situation, once SIRT1 finishes DNA repair then it returns to guard duty and re-establishes proper gene regulation that may have gone awry while it was gone.

The researchers proved that one common theme of aging is that SIRT1 is not on guard duty adequately.  Aging is invariably accompanied by too many wrong gene signals activated too often.  The greater the DNA damage the faster the aging, due in no small part to the improper gene activation (not necessarily the DNA damage itself).

The researchers also found that giving resveratrol to mice that lacked adequate SIRT1 for proper guard duty restored their gene signals to healthy and reversed aging.  This is a major breakthrough in anti-aging science. 

At the beginning of the study, with most participants in their 50s, they were running four hours per week.  Twenty years later they averaged 76 minutes per week and still felt running helped them maintain their obvious higher quality of health.  Running turns on gene switches that help maximize your potential to be healthy.  There is clear scientific evidence showing that we are all “born to run.” Running raises endorphins and boosts your supply of the vital brain repair compound called BDNF (which also helps you eat less food).

During my 30s and 40s I used to run 20-25 miles a week.  Now, I’m simply happy to be out running.  I do three 5 mile runs a week, and go slower than I used to.  However, I get just as good a metabolic response to running as I used to.  I attribute this to my use of nutrition prior to running, which helps me get the most out of the exercise I do.  Here is a list of my favorite running nutrients, which I take just prior to running:

1) Pantethine.  I call pantethine “runner’s high in a bottle.” It fuels the production of energy in numerous ways, providing great support for your adrenals, your mood, and your ability to mobilize fat into calorie burning while you run.  I take 600 mg before running (2 caps).
2) Cardio Helper.  I call Cardio Helper “oxygen in a bottle.” I simply cannot believe how much more oxygen I feel in my body when taking 2 capsules of Cardio Helper before running.  As any runner knows, the more oxygen you have going the less lactic acid gets in the way.
3) Muscle Mag.  Muscle Mag provides magnesium, malic acid, and related co-factors that reduce muscle fatigue and reduce the rate at which muscles make lactic acid while running.  It is a lot easier to maintain a higher-level aerobic pace for an extended period of time with Muscle Mag (2 caps before running).
4) Q10.  I call Q10 the “cellular spark plug.” If you are lacking Q10, as is typical with age, you simply cannot make energy efficiently and this includes the energy you need to get a positive benefit from running.  Q10 has been shown to help muscles function better and to turn on genes in muscles that help you burn fat while you exercise (200 mg before running).

That is my basic recipe for running.  It never fails me and I hope it helps you!

There has been an effort to try to better measure these functional thyroid problems.  A new calculation has emerged that is based on multiplying your T4 score by your TSH score.  TSH tells you how hard your brain is working to signal your thyroid to go.  As it rises, even within the normal range, it means your brain is trying to get more thyroid hormone into action. 

T4 levels usually drop in a frank hypothyroidism, as your thyroid gland just can’t make enough hormone.  However, before that happens, T4 levels actually rise.  This is a sign that T4 isn’t getting converted to T3 at the proper rate, in turn making cells behave as if they are receiving “hypothyroid-like directions” as not enough active thyroid hormone (T3) is signaling the cells.  This is the sluggish state of thyroid function, and as TSH levels rise out of the normal range it is called subclinical hypothyroidism. 

Even before subclinical hypothyroidism we have sluggish thyroid, which is accurately reflected by a rise in TSH (even within the normal range) and a rise in T4.  This shows “thyroid resistance” similar to the idea of insulin resistance.  The T4/TSH product is rapidly gaining credibility as a way to predict this early stage of thyroid trouble.

A new study just out shows that the T4/TSH product is a very accurate predictor of diastolic blood pressure (the lower number), as it progresses from completely healthy into various shades of elevated blood pressure.  This relationship held true regardless of insulin resistance or body mass index, indicating it is an independent risk variable for elevated blood pressure and consequent cardiovascular disease.  This information is important because it shows one of the very first types of changes that happen to a healthy person that start them in the wrong direction on a path of ever-worsening cardiovascular symptoms and problems.
The most common reason for elevating T4 and sluggish thyroid is a lack of the nutrient selenium that is needed to convert the T4 into T3, along with a lack of antioxidants to protect the thyroid gland and liver (the main site of T4 to T3 conversion).  These issues are easily compensated for with good thyroid support nutrition.

Using advanced technology (CD spectroscopy, photo-induced cross-linking of unmodified proteins, thioflavin T fluorescence, size exclusion chromatography, and electron microscopy) the researchers identified how grape seed extracts prevented the formation of disease-related amyloid β-protein (Aβ40 and Aβ42).

The researchers found that it was rather simple.  The grape seed extracts simply prevented amyloid proteins from folding into shapes that form plaque.  If they can’t fold they can’t form.  While these are animal studies and human trials will now get under way, the research is significant to tens of millions of Americans.

The authors summarized their findings “If the Aß proteins can’t assemble, toxic aggregates can’t form, and thus there is no toxicity. Our work in the laboratory, and Mt. Sinai’s Dr. Giulio Pasinetti’s work in mice, suggest that administration of the compound to Alzheimer’s patients might block the development of these toxic aggregates, prevent disease development and also ameliorate existing disease.”

This is not news to me but it is nice to see dieticians proving what I have been saying for years.  Rule #4 of the Leptin Diet is: Eat a breakfast containing protein.  Protein is like 2 x 4s and plywood showing up at your liver’s jobsite.  Metabolism is kicked into gear.  Protein, unlike carbohydrates, has to be taken apart and put back together again in combinations your body actually uses which significantly increases your metabolism.  A higher protein breakfast can boost your metabolic rate up to 30% for as long as 12 hours. 

High efficiency whey protein is a fast and easy breakfast that provides a low-calorie metabolic boost (Daily Protein Plus).  Never supplement with soy protein drinks.  They slow down metabolism due to soy’s anti-thyroid properties.

Elevated triglycerides interfere with leptin getting into your brain properly.  Triglycerides are little fat blobs.  Too many in your circulation is like having too many trucks on the freeway, slowing things down and generally getting in the way.  This is the first time a large study has directly linked them to strokes in a linear fashion (as the number goes up so does the stroke risk). 

The reason for the stroke increase was not explained by the study.  Once leptin resistance is induced by high nonfasting triglycerides then the surplus leptin communicates to leptin receptors on your platelets and makes them stickier.  This results in a combination of too much sludge in your circulation along with platelets that are primed to clot inappropriately.  I have been warning of this problem for years.  This study confirms it in a large population.

Exercise helps break down triglycerides to use as muscle fuel, which is one reason consistent exercise is invariably associated with better cardiovascular health.  In addition to the diet and exercise foundation, many nutrients have a favorable impact on helping triglycerides get out of your blood.  Those with extensive triglyceride-lowering science include DHA, pantethine, niacin, and chromium.  There are many others.  Any nutrient support that helps you manage leptin more effectively will assist you.

Maybe we should ask Big Pharma, who is spending a pile of cash on metabolites of resveratrol that they hope to patent as weight loss drugs, diabetes drugs, and a new generation of anti-aging medicines.  Part of the way resveratrol works is by activating a powerful metabolic fat-burning and anti-aging gene called SIRT1.  In newly published Big Pharma animal research their resveratrol drug activated SIRT1, prevented weight gain on a high fat diet, improved blood sugar and insulin function, and doubled the exercise endurance of the mice. 

Interestingly, resveratrol dietary supplements have been shown to do essentially the same thing.  The resveratrol drug (SRT1720) is apparently six times more potent at activating SIRT1 than plain resveratrol.  However, plain resveratrol operates in a number of different ways besides activating SIRT1, providing a broader base of potential health benefits including comprehensive cardiovascular support. 

What is Resveratrol?

Interest in resveratrol research took off when it was identified as a component in red wine that may be partly responsible for the “French Paradox,” the ability to eat a higher fat diet with less heart disease than Americans.  Research shows that resveratrol helps your liver metabolize fat and helps break down stored fat contained in your white adipose tissue.

Resveratrol is a type of polyphenol known as a stilbenoid, which is produced in grapes and blueberries to protect themselves from bacterial and fungal infection, and to a lesser extent from UV radiation.  It was discovered that grapes growing in damp and moldy areas had the highest content of resveratrol of any known commonly consumed food/beverage.  Resveratrol is obviously a potent anti-fungal compound and antioxidant.

Resveratrol is a different compound than the flavonoid proanthocyanidins of grape seed extracts, which also contribute to the notion of the French Paradox.  Blueberries, by comparison, also contain flavonoids and a different stilbenoid called pterostilbene (pronounced “tero-STILL-bean"). Significant research at the USDA has shown that pterostilbene has a powerful ability to influence the metabolism of cholesterol and the synthesis of triglycerides by improving metabolism within cells, as well as providing brain-protecting anti-aging properties. 

The amount of resveratrol in a bottle of red wine varies from 2 mg to 14 mg, mostly on the lower side.  Dietary supplements of resveratrol are typically derived from the roots of Japanese knotweed (Polygonum cuspidatum), a far more economical source than grapes.  Doses will range from a basic protective dose of a few milligrams (like a bottle of red wine), up to 100 mg per serving or more (a therapeutic dose).  It is readily absorbed, reaching peak blood levels in 30 minutes, and then rather rapidly cleared by your liver.  Thus, it is better to spread out intake during the day than take a large amount all at once.

At this point, other than the colorful history and longevity benefits associated with red wine consumption, the majority of the extensive resveratrol research has been carried out with cell studies and small animals.  The implications of this research are mind-boggling, clearly showing significant extension of life span. 

The Fat-Burning and Anti-Aging Properties of Resveratrol

SIRT1 first drew attention as the primary gene signal involved with the longevity benefits of calorie restriction. A very simple explanation is that when you are in a food scarcity situation, SIRT1 is activated so as to help break down your stored fat to use as fuel as well as to boost up your energy so that you have enough energy to hunt for new food.  SIRT1 is part of a famine-related survival system.

Many experiments with animals show that by restricting calorie intake SIRT1 is naturally activated, a finding that goes along with a noticeably extended lifespan, better fat and cholesterol metabolism, more efficient immune function, and better cardiovascular health.  A number of humans have taken up calorie restriction experiments on themselves, and pictures of them do not portray the portrait of health.  In fact, you would be hard pressed to pick out of a line-up someone on a self-induced calorie restriction diet and someone coming in for anorexia treatment.  Which gets to my point, what is the difference between a calorie restriction diet and anorexia? 

I have studied the calorie restriction science for 20 years and I am also the leading diet expert on the fat-derived hormone leptin, which is the overall boss hormone that controls your metabolic rate and your ability to survive a period of famine.  Thus, I will give you answers in this area that you won’t find elsewhere.  There is a very fine line between prolonged calorie restriction and anorexia.

In the case of someone consuming too much food, their extra pounds of fat crank out inflammatory messengers (TNFa and IL6), in turn stimulating the liver to make the inflammatory CRP.  This combination of inflammation induces significant free radical damage in the circulatory system and all around the body.  As the waistline expands the volume knob on inflammation and free radical production is turned up.  At the same time the liver becomes clogged with fat, which in turn is “cooked” by free radicals from the inflammation, eventually sending the liver on the path to looking like a fried piece of bacon.  Arteries are also getting fat around the outside of the arterial wall structure, in turn generating more inflammation to the inside of arteries and deactivating friendly nitric oxide production.  This makes blood pressure go up and blood not flow well and further induces free radical production in arteries that damages LDL cholesterol, promoting the formation of plaque. 

In this scenario leptin levels are also high (leptin resistance), which lowers another fat-derived hormone called adiponectin, in turn causing a bad mood and insulin resistance that leads to type II diabetes.  Leptin problems cripple thyroid function as well as promoting never-ending cravings to eat more food.  This is the precise metabolic profile of millions of Americans on the fast track to diabetes, heart disease, and poor health.  Ironically, they are being poisoned to death by too much food with no easy way out of the misguided subconscious drive to continue excess eating.

It is important to understand that just about everyone who is overweight and having trouble with their cravings has high leptin in their blood (leptin resistance), and that leptin is not getting into their brains correctly (a false state of misperceived starvation).  Leptin resistance is caused by consistently eating meals that are too large, by eating after dinner at night, and by snacking. 

Human beings do not have the genes to deal with the abuse of eating too much food, as during evolution this was never the problem.  Rather, a scarcity of food was the primary issue that constantly threatened the survival of the human race – and so it is that we have a lot of mechanisms built in to help deal with starvation.  The ability to survive famine is controlled by leptin.  During famine leptin levels have gone low as your fat mass that secretes leptin in the first place has been reduced in size to use the stored fat for energy, which is how your subconscious brain knows a famine is occurring.  In response to this low-leptin famine issue, your liver turns on the production of SIRT1.  This helps your liver know to break down fat to use as fuel, not store calories as fat, as well as to boost physical energy to be able to hunt or gather new food.

Considering all the interest in both SIRT1 and leptin, the number of studies linking the function of the two is remarkably absent from the literature.  New research shows that SIRT1 is active in key regions of your brain that relate to appetite and energy, which are governed by leptin.  Leptin deficient mice do not activate SIRT1 properly, and are always obese.  The details of this relationship are far from clear.  It is easy to predict that low levels of leptin from true starvation are able to trigger SIRT1 activation in your liver based on messages received from SIRT1 signaling systems in your brain.  It is also easy to predict that high levels of leptin in your blood (obesity-related leptin resistance) turn SIRT1 off as they would be signaling your liver that famine is over or not happening. 

As you begin to diet (especially if you follow the Leptin Diet) and drop your first 10-15 pounds you will clear high leptin from your blood, which is always reflected by your cravings going away.  For a while your body is set to burn more calories based on your pre-dieting metabolic set point.  The problem for many people is that you hit a plateau after a month or so of dieting that is too far from your goal weight.

If you eat less you can’t function.  Your head is heavy, you are irritable, your sleep gets disturbed, your immune system goes on the blink, and you are much more likely to get sick.  If you exercise more you must eat more or you will be completely exhausted and feel even worse.  If you get stressed, unlike the stress-free monkeys practicing calorie restriction, you are in real trouble and likely to eat the house down.  Yes, you are practicing calorie restriction – how on earth is this state of feeling going to help you live longer?  Answer – its not.  You start generating inflammation the longer you are in this condition.  The inflammation is no longer coming from your extra pounds of fat.  It is coming from the trauma of the diet combined with stressors in your life. 

Under these circumstances you are much more likely to break down muscle, a key sign of inappropriate weight loss.  If you keep trying to lose weight while you feel this way you may be able to do so, but you will progressively lose more muscle, increase inflammation, generate a lot of free radical damage, disturb digestion, get sick really easily, and presto – you are anorexic.  Funny thing is, you may still be an overweight anorexic.  Wow – is that any way to diet? 

If you start eating more food you will feel much better.  Unfortunately, you messed with leptin in the wrong way.  Leptin now turns off SIRT1 and goes into a famine-recovery mode.  It commands that a large portion of the calories you are now eating go back to fat storage.  Most people find themselves rapidly gaining weight on formerly normal amounts of food.  Once the yo-yo routine comes to a halt you are likely to find yourself 5-10 pounds heavier than when you first started, as an insurance policy in case you attempt another dieting stunt in the future.

Solving this dilemma requires that you eat in harmony with leptin, which means following the five simple rules of the Leptin Diet.  In many cases you will never hit this problematic plateau.  However, many people will, especially if they have a history of yo-yo dieting.  Enter resveratrol.  Resveratrol is an ideal nutrient to enhance weight loss and maintain energy ONCE YOU HAVE GOTTEN PAST THE INITITAL PHASE OF 10-15 POUNDS OF WEIGHT LOSS, especially if you are getting stuck at a plateau.

Resveratrol will help turn on the SIRT1 gene, which will promote fat-burning in the presence of lower calorie intake.  This is a terrific use of this nutrient.  How do you know its working?  You have energy to exercise, you feel good, and your weight is trending downward while you are happy eating less food.  This either is or isn’t happening, thus it isn’t very hard to figure out if resveratrol helps you.

One of the real values of this nutrient in the weight management context is helping you to not slide into an inflammatory anorexic-like metabolic problem as you try to lose weight.  It is also a tool to help you break through weight loss plateaus should they occur.  Resveratrol will work best when you are eating less food and have already cleared surplus leptin out of your blood through initial dieting efforts.  However, you don’t need to eat so little that you are on the scarecrow diet.

Research indicates that resveratrol will still help you out even if you aren’t dieting or you don’t need to lose weight.  After all, the French had resveratrol in their diet when they were mostly thin.  I might point out, however, that while the French were eating a higher saturated fat diet they were not overeating, their food was fresh and mostly organic, and they did not snack.  The effects of resveratrol will be easily overloaded by overeating.  Even the French Paradox has been doomed by an epidemic of leptin-disrupting snacking and junk food consumption.

Having a large waistline is clearly linked to premature death, a risk that goes up in direct proportion to your waistline’s rate of expansion.  Anything safe and natural that can help you get it back to optimal and keep it that way qualifies as life extending.

Cardiovascular and Other Benefits of Resveratrol

Simply losing weight healthfully will improve your cardiovascular health.  If resveratrol is able to help you in this endeavor, regardless of any other cardiovascular help it provides, then it is a success as a cardio-friendly nutrient. 

There is plenty of animal and cell science to predict that resveratrol assists the healthy structure and function of your cardiovascular system in multiple ways.  It has been found to reduce the stickiness or adherence of immune cells to the walls of arteries, prevent adverse changes in the smooth muscle cells of arteries that lead to plaque accumulation, boost friendly nitric oxide levels (eNOS) that relax arteries and improve blood flow, help keep platelets from sticking together, reduce irregular heart beats, and reduce circulatory inflammation.  It even helps protect against circulatory damage from high blood sugar.  Keep in mind that in “modern” medicine, each one of these points requires a different drug that has other adverse side effects.

One of the first human resveratrol studies shows that resveratrol improved heart function in type II diabetic patients following a heart attack.

Resveratrol, like grape seed extract, operates in part as a protector of human body structure.  This is clearly related to its anti-oxidant and anti-inflammatory properties, which include regulation of the primary inflammatory gene switch NF-kappaB.  New animal and cell studies shows it helps bone health, reduces cataracts, helps coordination, reduces disk deterioration and protects joints, guards against Parkinson’s, improves erectile performance, protects the liver, protects the pancreas, and helps regulate cell health while protecting against adverse cell changes.

This is a rather impressive array of science-backed support for any one nutrient.  Maybe the anti-aging promise is real.  The explosion of scientific interest in the compound ensures that you will be hearing a lot more about it in the very near future.

Common doses of resveratrol that show benefit and safety in animal studies range from 2.5 mg – to 10 mg per kilogram.  This translates to an approximate dose range of 150 mg – 700 mg per day for a 150 pound adult, a sensible and safe dose range until more data is in.