Health Topics

Substance P, Stress,
and Heart Function

Substance P is a neuropeptide that is involved in the natural regulation of many aspects of your cardiovascular system. Under normal circumstances it helps control vascular relaxation and thus blood pressure by enhancing the formation of nitric oxide. It also promotes the normal movement of fluids out of blood vessels for a variety of reasons. The main receptor for Substance P is called neurokinnin 1, NK1, which is located in many places throughout the body including the circulatory system and the heart itself. This means that substance P is a common regulatory compound used by your nervous system.

As it turns out, substance P is also the main way your body processes pain and intense stress. Under routine stress, your body simply turns up the volume on nerve activity and energy production. When the stress is over, everything is supposed to recover. If it doesn’t, your body enters a wear and tear trend. Substance P is not used as a basic coping mechanism for low-grade stress.

However, extra substance P kicks in when stress is more intense. This could occur as an acute high level of emotional stress, physical pain, an injury, an accident, or ongoing stress of an energy depleting emotional nature. Substance P is highly inflammatory by nature, a natural method of helping to deal with acute stress but problematic if stress is ongoing.

Signs of too much substance P include disrupted sleep, poor stress tolerance, ongoing fatigue, anxious or hostile feelings, restless legs, increased general aches or pains, skin related issues, respiratory stress, and/or digestive inflammation.

Unfortunately, too much substance P, instead of helping normal cardiovascular function, is a major irritant to the heart itself; it disrupts the vagal tone of the nervous system that is needed to support proper Heart Rate Variability and healthy heart rhythms.

All of the nutrients listed in this section so far contribute to the overall bank account reserves of your nervous system to help maintain natural balance, which helps keep extra substance P in check. Lifestyle factors that promote relaxation, fitness, and improved breathing, for example, all contribute to the same type of health benefits. In addition to these basic approaches a few more key points will help you understand substance P.*

Quercetin and Substance P

Substance P can be released in the brain stem or from any nerve ending. Once released, it triggers mast cells to release more histamine, which in turn promotes more substance P release by more nerve cells. This means that if you get stuck in a substance P rut in can be self-sustaining and somewhat hard to get out of. Quercetin is nature's most potent natural stabilizer of mast cells. It helps mast cells not release histamine so easily by helping reduce the cycle of ongoing substance P activation.*

Our quercetin capsules provide 500 mg per capsule, 1 to 6 per day can be used, as needed. Besides substance P issues, signs of need include mild allergy, pollen sensitivity, skin sensitivity (such as itching), sinus issues, and/or digestive issues.*

Repair Plus, A Novel Approach to Nerve-Heart Health

Repair Plus™ contains 100 mg of quercetin per capsule, in addition to bromelain, papain, and curcumin. Bromelain, a natural proteolytic enzyme, has been shown to directly decrease levels of substance P. It is known that enzymes degrade substance P and bromelain and papain provide your body with a boost in its natural supply of such anti-wear and -tear enzymes.*

Consider adding Repair Plus™ to your program based on overall aches as well as the general feeling of wear and tear. Repair Plus™ works synergistically with many other nutrients that support healthy tissue formation, and is thus part of a natural rejuvenation strategy.*

Quercetin Quercetin

Naturally helps remove excessive substance P from nerves. Take 1-2 at bedtime, or use during the day to help prevent a buildup that interferes with sleep.*

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Repair Plus™ Repair Plus™

Contains nutrients that help "eat up trash" in the blood and lymph. It supports the natural process of repair and rejuvenation.*

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