Tangeretin and Nobiletin Lower Cholesterol by Inhibiting ApoB Production

By: Byron J. Richards, Board Certified Clinical Nutritionist
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Tangeretin and nobiletin are polymethoxylated citrus flavonoids which have been studied for a number of years for their ability to help lower LDL cholesterol. The latest study demonstrates that their primary activity is to inhibit the production of ApoB1 by liver cells. ApoB is required for the formation of LDL cholesterol, so if there is less ApoB produced then there has to be less LDL cholesterol.

ApoB (Apolipoprotein B) is a protein that binds on to fatty structures to form LDL cholesterol. LDL also needs ApoB so that cells around your body can recognize LDL coming and enable it to bind to cells and drop of its packages. Some ApoB and some LDL are obviously a good thing. However, high levels of ApoB are even more predictive of heart disease than high levels LDL itself. Mutations in the gene that encodes ApoB, resulting in excessive ApoB production, is the primary reason for familial high cholesterol levels. Thus, finding ways to reduce ApoB production, especially in those with family issues, is a very good thing for heart health.

The researchers found that tangeretin and nobiletin have flavonoids with an ideal chemistry structure to bind on to liver cells in a way that inhibits ApoB secretion. This is one of many angles that a person can employ to help modulate their cholesterol levels with natural methods.

Referenced Studies:
  1. ^ Tangeretin and Nobiletin Reduce ApoB Secretion  J Agric Food Chem.   Lin Y, Vermeer MA, Bos W, van Buren L, Schuurbiers E, Miret-Catalan S, Trautwein EA.

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