Tangeretin and Nobiletin Lower Cholesterol by Inhibiting ApoB Production

Wednesday, July 20, 2011
By: Byron J. Richards,
Board Certified Clinical Nutritionist
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Tangeretin and nobiletin Type of citrus bioflavonoid shown to have anti-inflammatory, anti-oxidant, and blood sugar support properties. are polymethoxylated citrus flavonoids Plant compound that is associated with pigmentation. Flavonoids have been shown to modify allergens, viruses, inflammation, and various carcinogens. Found in green tea, citrus, berries, onions, parsley, red wine, dark chocolate, and others. which have been studied for a number of years for their ability to help lower LDL cholesterol Low-density lipoprotein. It is a group of lipids and proteins that allow lipids like cholesterol, triglycerides, and fat soluble nutrients (Vitamin A, D, E , K, Q 10, carotenes) to be transported with the water-based bloodstream. .  The latest study demonstrates that their primary activity is to inhibit the production of ApoB1 by liver cells. ApoB is required for the formation of LDL cholesterol Low-density lipoprotein. It is a group of lipids and proteins that allow lipids like cholesterol, triglycerides, and fat soluble nutrients (Vitamin A, D, E , K, Q 10, carotenes) to be transported with the water-based bloodstream. , so if there is less ApoB produces then there has to be less LDL cholesterol Low-density lipoprotein. It is a group of lipids and proteins that allow lipids like cholesterol, triglycerides, and fat soluble nutrients (Vitamin A, D, E , K, Q 10, carotenes) to be transported with the water-based bloodstream. .

ApoB (Apolipoprotein B) is a protein that binds on to fatty structures to form LDL cholesterol Low-density lipoprotein. It is a group of lipids and proteins that allow lipids like cholesterol, triglycerides, and fat soluble nutrients (Vitamin A, D, E , K, Q 10, carotenes) to be transported with the water-based bloodstream. . LDL also needs ApoB so that cells around your body can recognize LDL coming and enable it to bind to cells and drop of its packages. Some ApoB and some LDL are obviously a good thing. However, high levels of ApoB are even more predictive of heart disease than high levels LDL itself. Mutations in the gene that encodes ApoB, resulting in excessive ApoB production, is the primary reason for familial high cholesterol levels. Thus, finding ways to reduce ApoB production, especially in those with family issues, is a very good thing for heart health.

The researchers found that tangeretin Special type of citrus bioflavonoid shown to reduce the risk for certin cancers, protecting nerve cells, and involved with healthy cholesterol function. and nobiletin Type of citrus bioflavonoid shown to have anti-inflammatory, anti-oxidant, and blood sugar support properties. have flavonoids Plant compound that is associated with pigmentation. Flavonoids have been shown to modify allergens, viruses, inflammation, and various carcinogens. Found in green tea, citrus, berries, onions, parsley, red wine, dark chocolate, and others. with an ideal chemistry structure to bind on to liver cells in a way that inhibits ApoB secretion. This is one of many angles that a person can imploy to help modulate their cholesterol levels with natural methods.


Referenced Studies:
  1. ^ Tangeretin and Nobiletin Reduce ApoB Secretion  J Agric Food Chem.   Lin Y, Vermeer MA, Bos W, van Buren L, Schuurbiers E, Miret-Catalan S, Trautwein EA.

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