Statins Increase Delirium Rate After Surgery

Statins have so many adverse side effects they are getting hard to count.  If you are 65 or older, taking a statin Class of drugs aka HMG-CoA reductase inhibitors, that are used to lower cholesterol levels by inhibiting the HMG-CoA reductase enzyme that plays a central role in liver function and cholesterol production., and go in for an elective surgery of any type, you are 28% more likely to have delirium following the surgery¹.  This is because statins injure your brain cells over time and handicap your response to stress.  A surgery, even if it goes smoothly, is stressful to your body.  Statins increase the likelihood your body will not be able to deal with this stress, in this case resulting in delirium.  However, this principle is likely to apply to any form of stress – meaning that statins have a generalized effect in terms of reducing your ability to mentally cope.

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