Pterostilbene: A Cholesterol and Blood Sugar Improving Anti-Cancer Nutrient

Pterostilbene, like its cousin resveratrol Natural phenol or type of antioxidant found in red grapes, red wine. Research has shown beneficial effects as anti-cancer and anti-inflammatory agents along with supporting healthy blood sugar and cardiovasculature function., is gaining world-wide attention for its rather dramatic ability to improve human health, protect against the diseases of aging, and extend lifespan¹.

Pterostilbene is found in small amounts in blueberries and grapes, but the most cost effective source is from the bark and heartwood of a tree that grows in India and Sri Lanka (Pterocarpus marsupium or Indian Kino Tree). 

Pterostilbene for Blood Sugar and Lipid Metabolism

Extracts of Pterocarpus marsupium have been used in Ayurvedic medicine for several thousand years for the treatment of diabetes. Modern day animal research on Pterocarpus marsupium helps support its traditional folk medicine use, showing it can:

1. Rejuvenate beta cells in the pancreas² (the cells that produce insulin).
2. Prevent elevated blood sugar, triglycerides, and insulin resistance from a high fructose diet³.
3. Lower weight, blood sugar, and inflammation in Type 2 diabetes⁴.
4. Lower triglycerides, total cholesterol, and LDL- and VLDL-cholesterol in diet-induced hyperlipidemia⁵.

In today’s marketplace extracts of Pterocarpus marsupium can be standardized for its most important biologically active compound, pterostilbene⁶ (pronounced “tero-STILL-bean”). This nutrient is a type of polyphenol known as a stilbenoid, as is resveratrol Natural phenol or type of antioxidant found in red grapes, red wine. Research has shown beneficial effects as anti-cancer and anti-inflammatory agents along with supporting healthy blood sugar and cardiovasculature function..  Stilbenoids are very small molecules that are readily absorbed, wherein they participate in antioxidant systems, anti-inflammatory systems (lowering NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. and unfriendly nitric oxide⁸), and can have profound regulatory impact on multiple gene signals. Pterostilbene has two methoxy and one hydroxyl group, whereas resveratrol Natural phenol or type of antioxidant found in red grapes, red wine. Research has shown beneficial effects as anti-cancer and anti-inflammatory agents along with supporting healthy blood sugar and cardiovasculature function. has three hydroxyl groups. These small differences in an otherwise identical structure enable quite different function. For one thing this enables pterostilbene to be absorbed into cells easier and makes it slower to be cleared out of the body, compared to resveratrol Natural phenol or type of antioxidant found in red grapes, red wine. Research has shown beneficial effects as anti-cancer and anti-inflammatory agents along with supporting healthy blood sugar and cardiovasculature function..  Pterostilbene excels as an antioxidant between cells (such as inflammatory tissue damage⁹) whereas reseveratrol excels at protecting cells in the blood.  Resveratrol specializes in activating the longevity gene SIRT1 Considered the "longevity protein" known for its life spanning effects. It has been shown to inhibit cancer and promote longevity., whereas pterostilbene has a profound effect on the fat/lipid metabolizing gene PPAR (both nutrients activate many genes). Stilbenoids are synthesized by plants in response to infectious attack, making them excellent immune support nutrients. The unique structure of pterostilbene makes it 5-10 times as potent an anti-fungal as resveratrol Natural phenol or type of antioxidant found in red grapes, red wine. Research has shown beneficial effects as anti-cancer and anti-inflammatory agents along with supporting healthy blood sugar and cardiovasculature function.. 

When pterostilbene enters a cell, it easily binds to the receptors for PPAR activation¹⁰, enabling improved metabolism of triglycerides, cholesterol, and blood sugar. Hamster studies show that PPAR activation with pterostilbene¹¹ lowered LDL cholesterol Low-density lipoprotein. It is a group of lipids and proteins that allow lipids like cholesterol, triglycerides, and fat soluble nutrients (Vitamin A, D, E , K, Q 10, carotenes) to be transported with the water-based bloodstream. by 29%, lowered blood sugar by 14%, and boosted protective HDL Cholesterol High-density lipoprotein that is one of five lipoproteins that enable cholesterol and triglycerides to be transported within the bloodstream to the liver and to the adrenals, ovaries, or testes for the production of steroid hormones. by 7%. 

The major problem of high blood sugar is that it caramelizes healthy body structure by forming advanced glycation end products (AGEs), thereby speeding the decline of the kidneys, heart, eyes, and all things flexible. A new study shows that pterostilbene can directly block the formation of AGEs¹². Another study showed that pterostilbene lowered hemoglobin A1C¹³ in diabetic rats (a marker that predicts AGEs formation). And yet another study showed that this versatile nutrient prevented damage to the liver and kidneys¹⁴ of diabetic rats.

The abnormal proliferation of cells within the walls of arteries takes place during the plaque formation process. An animal study shows that pterostilbene¹⁵ inhibited this undesirable process. The researchers concluded that “pterostilbene may be a potential anti-proliferative agent for the treatment of atherosclerosis.”

The metabolic science on pterostilbene along with its traditional folk use, warrant its inclusion along with other synergistic nutrients to support healthy metabolism of lipids and blood sugar.

Pterostilbene as an Anti-Cancer Nutrient

One of the great problems of being overweight is that it significantly boosts the risk for cancer including aggressive breast and prostate cancer. Not only does pterostilbene help support the return of normal metabolism, it is one of the most heavily researched anti-cancer compounds.

As a small molecule, pterostilbene has no problem gaining access into cancer cells. It appears to be a cancer cell’s worst nightmare. It damages a cancer cell’s membrane and DNA and induces death signals causing self-destruction. This was recently shown with studies of both breast and prostate cancer cells¹⁶.  In another recent breast cancer cell study, pterostilbene caused the energy-producing system within the cancer cell to malfunction and generate massive amounts of free radicals instead of energy, resulting in breast cancer cell death¹⁷. Similar findings have now been demonstrated with pancreatic cancer cells¹⁸. Pterostilbene has also been shown to inhibit colon cancer¹⁹, lung cancer²⁰, liver cancer²¹, and skin cancer²².

In a recent study with bladder cancer cells²³ pterostilbene was shown for the first time to activate the autophagy process wherein a cell is commanded to eat itself, thereby inducing cell death. In normal health, autophagy is used to help keep a cell clean, which prevents cancer. It is amazing, that the intelligence to help healthy cells and help kill cancer cells exists, by important mechanisms like autophagy.

Pterostilbene is a nutrient you are sure to hear more about. It works by multiple mechanisms at the gene level to promote metabolic health and the risk of cancer.