How Grape Seed Extracts Stop Alzheimer’s Plaque

By: Byron J. Richards, Board Certified Clinical Nutritionist

Earlier this year researchers published data showing that grape seed extract polyphenols could prevent Alzheimer’s plaque1 from forming in mice.  In their latest experiments2 they sought to determine exactly how grape seed extract was able to work its magic. 

Using advanced technology (CD spectroscopy, photo-induced cross-linking of unmodified proteins, thioflavin T fluorescence, size exclusion chromatography, and electron microscopy) the researchers identified how grape seed extracts prevented the formation of disease-related amyloid β-protein (Aβ40 and Aβ42).

The researchers found that it was rather simple.  The grape seed extracts simply prevented amyloid proteins from folding into shapes that form plaque.  If they can’t fold they can’t form.  While these are animal studies and human trials will now get under way, the research is significant to tens of millions of Americans.

The authors summarized their findings “If the Aß proteins can’t assemble, toxic aggregates can’t form, and thus there is no toxicity. Our work in the laboratory, and Mt. Sinai’s Dr. Giulio Pasinetti’s work in mice, suggest that administration of the compound to Alzheimer’s patients might block the development of these toxic aggregates, prevent disease development and also ameliorate existing disease.”

Referenced Studies:
  1. ^ Grape Seed Extract Reduces Alzheimer’s Plaque  The Journal of Neuroscience  Jun Wang, Lap Ho, Wei Zhao, Kenjiro Ono, Clark Rosensweig, Linghong Chen, Nelson Humala, David B. Teplow, and Giulio M. Pasinetti.
  2. ^ Mechanism of Grape Seed Extract Protection Against Alzheimer’s Disease  J. Biol. Chem  Kenjiro Ono, Margaret M. Condron, Lap Ho, Jun Wang, Wei Zhao, Giulio M. Pasinetti, and David B. Teplow.

More Health News

Loading articles...
Loading navigation...
Loading content...

View All Health News Archives
Supplement Advisor
Wellness Resources Success Stories
Connect on Facebook Follow us on Twitter Wellness Resources on Pinterest Wellness Resources YouTube Channel Get RSS News Feeds