Glutamine Maintains Gut Barrier Integrity Following E. Coli Exposure

Friday, June 03, 2011
By: Byron J. Richards,
Board Certified Clinical Nutritionist
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Glutamine continues to shine as a stellar nutrient for GI tract health, both in terms of assisting GI tract immunity and helping the health of the GI tract lining.  The latest animal study shows that when pigs are supplemented with glutamine1 and exposed to several different strains of infectious E.coli the GI tract is highly protected against the infectious attack.  Americans should be aware of this fact, and Germans should be acting on it in the face of their nasty outbreak.

Of particular interest is that glutamine significantly reduced the inflammatory signals that E. coli generates so as to induce tissue damage. Furthermore, the tight junction proteins that are the foundation for a healthy gut barrier maintained full functionality with glutamine supplementation. If these tight junction proteins become inflamed and lose their “tightness” then the gut becomes leaky and toxins and even germs can enter the general circulation.

This study clearly shows the value of glutamine to help deal with infectious E. coli exposure. The mechanisms of help are likely to apply to many “germ gangs” that would otherwise have an easier time of wreaking havoc with digestive, immune, and metabolic health.


Referenced Studies:
  1. ^ Glutamine Helps Protect GI Tract from E. Coli Exposure  Nutritional Immunology  Julia B. Ewaschuka, Gordon K. Murdocha, Ian R. Johnsona, Karen L. Madsena and Catherine J. Fielda.

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