DHA Regulates Inflammatory Gene Function

Friday, April 10, 2009 - Byron J. Richards, CCN

The more you learn about DHA the more important you realize it is.  A new study analyzing its molecular workings found that DHA reduced inflammation (IL6 signaling) by directly regulating the gene transcription signal from immune cells that otherwise produces inflammation.  This finding is significant as the production of IL6 (and TNFa) from stored fat is a primary mechanism by which obesity generates inflammatory-related disease.

The scientist found that DHA inhibited cAMP response element-binding protein (CREB), an important gene transcription factor, thus turning down the volume knob on inflammatory gene signaling.  In macrophages this result occurred within three hours.  Mice fed DHA as part of their diet for 6-8 weeks also displayed much less IL6 activity in their macrophages.

New science continues to prove the extreme importance of omega 3 fatty acids, especially DHA, as a key nutrient in the regulation of health.  This nutrient was in higher proportion during historical times and is now woefully lacking in the American diet   Supplementation is a necessity for most people.

Related Entries: DHA Helps Combat Cancer
DHA Lowers Inflammation in Men with Metabolic Problems
DHA Rejuvenates Aging Brain Cells
DHA Reduces Inflammation
DHA Found to Protect against Alzheimer’s
High Intake of EPA/DHA Reduces Risks for Cardiovascular Disease

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