Citrus Flavonoids Lower Cholesterol

By: Byron J. Richards, Board Certified Clinical Nutritionist

Previous studies have shown that citrus flavonoids lower cholesterol in humans.  A new study seeks to understand exactly how this is done, and it shows that the citrus flavonoids1 work at the gene level to enhance the natural metabolism of cholesterol by the liver with consequent improvement in cellular metabolism of fat.

There are many different angles to cholesterol fitness – because cholesterol is doing so many useful things in your body.  Nutrients that help guide cholesterol into proper function are the preferred way to enhance cardiovascular health as this strategy works in harmony with what you body wants to do.

The citrus flavonoids studied are unique compounds called polymethoxylated flavones (PMF).  They were shown to activate genes in a way that helps cells use cholesterol more efficiently, in general enhancing the metabolism of fatty acids in cells by helping to activate sterol regulatory elements.  It is actually rather amazing how well our bodies use nutrition to promote health.

Referenced Studies:
  1. ^ Citrus Flavonoids Boost Cholesterol Fitness  Journal of Nutrition  Brian Morin, LaNita A. Nichols, Katherine M. Zalasky, J. Wade Davis, John A. Manthey and Lené J. Holland.

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